The regulatory roles of circular RNAs via autophagy in ischemic stroke

Xiaoqin Li; Lingfei Li; Xiaoli Si; Zheng Zhang; Zhumei Ni; Yongji Zhou; Keqin Liu; Wenqing Xia; Yuyao Zhang; Xin Gu; Jinyu Huang; Congguo Yin; Anwen Shao; Lin Jiang

doi:10.3389/fneur.2022.963508

The regulatory roles of circular RNAs via autophagy in ischemic stroke

Front Neurol. 2022 Oct 18:13:963508. doi: 10.3389/fneur.2022.963508. eCollection 2022.

Authors

Xiaoqin Li¹, Lingfei Li², Xiaoli Si³, Zheng Zhang¹, Zhumei Ni⁴, Yongji Zhou², Keqin Liu², Wenqing Xia², Yuyao Zhang¹, Xin Gu¹, Jinyu Huang⁵, Congguo Yin^{1

2}, Anwen Shao^{6

7}, Lin Jiang^{1

2}

Affiliations

¹ The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
² Department of Neurology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
³ Department of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
⁴ Department of Emergency, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
⁵ Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
⁶ Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
⁷ Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Disease, Hangzhou, China.

Abstract

Ischemic stroke (IS) is a severe disease with a high disability, recurrence, and mortality rates. Autophagy, a highly conserved process that degrades damaged or aging organelles and excess cellular components to maintain homeostasis, is activated during IS. It influences the blood-brain barrier integrity and regulates apoptosis. Circular RNAs (circRNAs) are novel non-coding RNAs involved in IS-induced autophagy and participate in various pathological processes following IS. In addition, they play a role in autophagy regulation. This review summarizes current evidence on the roles of autophagy and circRNA in IS and the potential mechanisms by which circRNAs regulate autophagy to influence IS injury. This review serves as a basis for the clinical application of circRNAs as novel biomarkers and therapeutic targets in the future.

Keywords: autophagy; biomarkers; circRNA; ischemic stroke; therapeutic targets.

Publication types

Review