A pilot study comparing myelin measurements from myelin water imaging and 11C-PIB PET in multiple sclerosis

Irene M Vavasour; Nasim Vafai; Philippe Beauchemin; Chironjeev Kanjilal; Alexandru Badalan; Elham Shahinfard; Cornelia Laule; David Kb Li; Anthony Traboulsee; Vesna Sossi; Shannon H Kolind; Robert L Carruthers

doi:10.1016/j.msard.2022.104238

A pilot study comparing myelin measurements from myelin water imaging and ¹¹C-PIB PET in multiple sclerosis

Mult Scler Relat Disord. 2022 Dec:68:104238. doi: 10.1016/j.msard.2022.104238. Epub 2022 Oct 17.

Affiliations

¹ Radiology, University of British Columbia, Vancouver, Canada; International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada. Electronic address: lees@phas.ubc.ca.
² Medicine (Neurology), University of British Columbia, Vancouver, Canada.
³ Département de Médecine, Université Laval, Ville de Québec, Canada.
⁴ Physics & Astronomy, University of British Columbia, Vancouver, Canada.
⁵ Radiology, University of British Columbia, Vancouver, Canada; International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada; Physics & Astronomy, University of British Columbia, Vancouver, Canada; Pathology & Laboratory Medicine, University of British Columbia, Vancouver, Canada.
⁶ Radiology, University of British Columbia, Vancouver, Canada.
⁷ Medicine (Neurology), University of British Columbia, Vancouver, Canada; Physics & Astronomy, University of British Columbia, Vancouver, Canada.
⁸ Radiology, University of British Columbia, Vancouver, Canada; International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada; Medicine (Neurology), University of British Columbia, Vancouver, Canada; Physics & Astronomy, University of British Columbia, Vancouver, Canada.

PMID: 36274287
DOI: 10.1016/j.msard.2022.104238

Abstract

MRI-based myelin water fraction (MWF) and PET-based Pittsburgh compound B (PiB) imaging both have potential to measure myelin in multiple sclerosis (MS). We characterised the differences in MWF and PiB binding in MS lesions relative to normal-appearing white matter and assessed the correlation between MWF and PiB binding in 11 MS participants and 3 healthy controls within 14 white matter regions of interest. Both PiB binding and MWF were reduced in MS lesions relative to NAWM, and a modest within subject correlation between MWF and PiB binding was found. This pilot study shows that MWF and PET-PiB provide different information about myelin loss in MS.

Keywords: Magnetic resonance imaging; Multiple sclerosis; Myelin, myelin water fraction; Pittsburgh compound B; Positron emission tomography.

Publication types

Letter

MeSH terms

Brain / pathology
Humans
Magnetic Resonance Imaging / methods
Multiple Sclerosis* / diagnostic imaging
Multiple Sclerosis* / pathology
Myelin Sheath / pathology
Pilot Projects
Water / analysis
White Matter* / pathology

Substances

Water