Clinical Implication of Genetic Testing in Dilated Cardiomyopathy

Ju-Hee Lee; Sang Eun Lee; Myeong-Chan Cho

doi:10.36628/ijhf.2021.0024

Clinical Implication of Genetic Testing in Dilated Cardiomyopathy

Int J Heart Fail. 2021 Oct 21;4(1):1-11. doi: 10.36628/ijhf.2021.0024. eCollection 2022 Jan.

Authors

Ju-Hee Lee^{1

2}, Sang Eun Lee³, Myeong-Chan Cho⁴

Affiliations

¹ Division of Healthcare and Artificial Intelligence, Department of Precision Medicine, National Institute of Health, Cheongju, Korea.
² Division of Cardiology, Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea.
³ Department of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
⁴ Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.

Abstract

Dilated cardiomyopathy (DCM) is one of the important causes of heart failure (HF). With the rapidly evolving technologies for gene analysis and tremendous advances in knowledge of HF genetics, the importance of genetic testing in DCM is currently highlighted. Several genetic variants causing DCM have been identified and this information is used for diagnosis, risk stratification and family screening of DCM patients. However, there are still several challenges in applying genetic testing to real clinical practice. In this review, we will summarize recent understandings in DCM genetics and provide an evidence-based practical guide to the use of genetic testing for DCM patients.

Keywords: Dilated cardiomyopathy; Genetics.

Publication types

Review