Human microglia phenotypes in the brain associated with HIV infection

Johannes C M Schlachetzki; Yi Zhou; Christopher K Glass

doi:10.1016/j.conb.2022.102637

Human microglia phenotypes in the brain associated with HIV infection

Curr Opin Neurobiol. 2022 Dec:77:102637. doi: 10.1016/j.conb.2022.102637. Epub 2022 Oct 1.

Authors

Johannes C M Schlachetzki¹, Yi Zhou², Christopher K Glass³

Affiliations

¹ Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093-0651, USA. Electronic address: jschlachetzki@ucsd.edu.
² Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093-0651, USA. Electronic address: https://twitter.com/jojoyizhou_JOY.
³ Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093-0651, USA. Electronic address: https://twitter.com/UCSDGlassLab.

PMID: 36194988
DOI: 10.1016/j.conb.2022.102637

Abstract

Cognitive impairment in individuals infected with HIV is highly prevalent despite life-long antiretroviral therapy. A growing line of evidence suggests that the human brain serves as a sanctuary for HIV persistence. Microglia, the innate immune cells of the brain parenchyma, may serve as a reservoir for HIV and drive the pathogenesis of HIV-associated neurocognitive disorders. Here, we highlight recent advances in understanding microglia diversity in HIV regarding their epigenome, transcriptome, and function.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Brain
HIV Infections* / complications
Humans
Microglia
Phenotype