Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression

Gastroenterology. 2023 Feb;164(2):289-292.e4. doi: 10.1053/j.gastro.2022.09.036. Epub 2022 Oct 1.

Authors

Dongni Fu¹, Brandon M Blobner¹, Phil J Greer¹, Robert Lafyatis², Melena D Bellin³, David C Whitcomb⁴; Prospective Autos Study; GREAT1 Study; North American Pancreatitis Study Group

Affiliations

¹ Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
² Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
³ Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.
⁴ Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine and, Department of Cell Biology and Molecular Physiology, and Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: whitcomb@pitt.edu.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Genetic Predisposition to Disease*
Haplotypes
Humans
Mutation
Pancreatitis, Chronic*
Receptors, Antigen, T-Cell
Trypsin / genetics
Trypsin / metabolism
Trypsinogen / genetics

Substances

Receptors, Antigen, T-Cell
Trypsin
Trypsinogen
PRSS2 protein, human
PRSS1 protein, human

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