Perspectives: Neonatal acute kidney injury (AKI) in low and middle income countries (LMIC)

Mignon I McCulloch; Victoria M Adabayeri; Selasie Goka; Tholang S Khumalo; Nilesh Lala; Shannon Leahy; Nokukhanya Ngubane-Mwandla; Peter J Nourse; Beatrice I Nyann; Karen L Petersen; Cecil S Levy

doi:10.3389/fped.2022.870497

Perspectives: Neonatal acute kidney injury (AKI) in low and middle income countries (LMIC)

Front Pediatr. 2022 Aug 31:10:870497. doi: 10.3389/fped.2022.870497. eCollection 2022.

Authors

Affiliations

¹ Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
² Korle Bu Teaching Hospital, Accra, Ghana.
³ Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, United States.
⁴ Nelson Mandela Children's Hospital, University of the Witwatersrand, Johannesburg, South Africa.
⁵ Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa.
⁶ Department of Paediatrics, University of Ghana Medical Centre, Accra, Ghana.

Abstract

Neonatal AKI (NAKI) remains a challenge in low- and middle-income countries (LMICs). In this perspective, we address issues of diagnosis and risk factors particular to less well-resourced regions. The conservative management pre-kidney replacement therapy (pre-KRT) is prioritized and challenges of KRT are described with improvised dialysis techniques also included. Special emphasis is placed on ethical and palliation principles.

Keywords: LMIC; conservative kidney management; neonatal KRT; neonatal acute kidney injury; neonatal peritoneal dialysis.