Two new species of longhorned beetles (Coleoptera: Cerambycidae) from Central America are described and illustrated: Crossomeles copei sp. nov. and Crossomeles oscarcastilloi sp. nov. (Cerambycinae: Rhinotragini) from Mexico and Costa Rica, respectively. A key to the known species of Crossomeles Chemsak Noguera, 1993 is provided. Also, two new country records are reported: Crossomeles acutipennis Chemsak Noguera, 1993 from Panama; and Oncideres fisheri Dillon Dillon, 1946 (Lamiinae: Onciderini) from the United States of America.