The role of protein arginine N-methyltransferases in inflammation

Ting Chen; Jinxin Liu; Shizhe Li; Peter Wang; Guanning Shang

doi:10.1016/j.semcdb.2022.08.005

The role of protein arginine N-methyltransferases in inflammation

Semin Cell Dev Biol. 2024 Feb 15;154(Pt C):208-214. doi: 10.1016/j.semcdb.2022.08.005. Epub 2022 Sep 6.

Authors

Ting Chen¹, Jinxin Liu¹, Shizhe Li¹, Peter Wang², Guanning Shang³

Affiliations

¹ Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.
² Bengbu Medical College Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Department of Biochemistry and Molecular Biology, School of Laboratory Medicine, Bengbu Medical College, Anhui 233030, China. Electronic address: wangpeter3@126.com.
³ Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China. Electronic address: gnshang@cmu.edu.cn.

PMID: 36075843
DOI: 10.1016/j.semcdb.2022.08.005

Abstract

Protein arginine methyltransferases (PRMTs) promote the methylation of numerous proteins at their arginine residues. An increasing number of publications have suggested that dysregulation of PRMTs participates in various human diseases, such as cardiovascular diseases, cancer, diabetes and neurodegenerative disorders. Inflammation is one normal response to infection or injury by immune system, which can keep body homeostasis. Emerging data reveal that inflammation is associated with the development of numerous diseases. Moreover, accumulated evidence proves that PRMTs have been characterized to regulate inflammation in various diseases. In this review article, we delineate the function and molecular mechanism of PRMTs in regulation of inflammation in current literature. Moreover, we discuss that targeting PRMTs by its inhibitors and compounds could have therapeutic potential.

Keywords: Asthma; Inflammation; Methylation; PRMTs; Therapy.

Publication types

Review