Persistent Circulating Severe Acute Respiratory Syndrome Coronavirus 2 Spike Is Associated With Post-acute Coronavirus Disease 2019 Sequelae

Clin Infect Dis. 2023 Feb 8;76(3):e487-e490. doi: 10.1093/cid/ciac722.

Abstract

The diagnosis of postacute sequelae of coronavirus disease 2019 (PASC) poses an ongoing medical challenge. To identify biomarkers associated with PASC we analyzed plasma samples collected from PASC and coronavirus disease 2019 patients to quantify viral antigens and inflammatory markers. We detect severe acute respiratory syndrome coronavirus 2 spike predominantly in PASC patients up to 12 months after diagnosis.

Keywords: COVID-19; SARS-CoV-2 antigens; long COVID; post-acute sequelae of COVID-19 (PASC); spike.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Viral* / blood
  • Antigens, Viral* / immunology
  • Biomarkers / blood
  • COVID-19* / blood
  • COVID-19* / complications
  • COVID-19* / immunology
  • Disease Progression
  • Humans
  • Post-Acute COVID-19 Syndrome* / blood
  • Post-Acute COVID-19 Syndrome* / diagnosis
  • Post-Acute COVID-19 Syndrome* / immunology
  • SARS-CoV-2*
  • Spike Glycoprotein, Coronavirus* / blood

Substances

  • Antigens, Viral
  • Biomarkers
  • spike protein, SARS-CoV-2
  • Spike Glycoprotein, Coronavirus

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