East Coast fever, a neglected tropical disease with an outdated vaccine approach?

Abstract

Since its discovery, bovine theileriosis has caused major socioeconomic losses in sub-Saharan Africa. Acaricide resistance of the intermediate host, paucity of therapeutics, and lack of sufficiently cross-protective vaccines increase the risk of parasite spread due to global warming. Here, we highlight three important areas that require investigation to develop next-generation vaccines.

Keywords: Theileria parva; cellular immunity; drug resistance; glycobiology; infection and treatment method (ITM); protein modelling.