miR-99a-5p modulates doxorubicin resistance via the COX-2/ABCG2 axis in triple-negative breast cancer: from the discovery to in vivo studies

Iris Garrido-Cano; Anna Adam-Artigues; Ana Lameirinhas; Juan F Blandez; Vicente Candela-Noguera; Federico Rojo; Sandra Zazo; Juan Madoz-Gúrpide; Ana Lluch; Begoña Bermejo; Felix Sancenón; Juan Miguel Cejalvo; Ramón Martínez-Máñez; Pilar Eroles

doi:10.1002/cac2.12352

miR-99a-5p modulates doxorubicin resistance via the COX-2/ABCG2 axis in triple-negative breast cancer: from the discovery to in vivo studies

Cancer Commun (Lond). 2022 Dec;42(12):1412-1416. doi: 10.1002/cac2.12352. Epub 2022 Aug 23.

Authors

Iris Garrido-Cano^{1

2}, Anna Adam-Artigues¹, Ana Lameirinhas¹, Juan F Blandez^{2

3

4

5}, Vicente Candela-Noguera³, Federico Rojo^{6

7}, Sandra Zazo⁷, Juan Madoz-Gúrpide⁷, Ana Lluch^{1

6

8

9}, Begoña Bermejo^{1

6

8}, Felix Sancenón^{2

3

4

5}, Juan Miguel Cejalvo^{1

6

8}, Ramón Martínez-Máñez^{2

3

4

5}, Pilar Eroles^{1

6

10}

Affiliations

¹ Biomedical Research Institute INCLIVA, Valencia, 46010, Spain.
² Bioengineering, Biomaterials and Nanomedicine Networking Biomedical Research Centre (CIBER-BBN), Madrid, 28029, Spain.
³ Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM), Polytechnic University of Valencia, University of Valencia, Valencia, 46010, Spain.
⁴ Joint Unit CIPF-UPV of Mechanisms of Diseases and Nanomedicine, Valencia, Polytechnic University of Valencia, Prince Felipe Research Center, Valencia, 46012, Spain.
⁵ Joint Research Unit in Nanomedicine and Sensors, Polytechnic University of Valencia, Medical Research Institute Hospital La Fe, Valencia, 46026, Spain.
⁶ Biomedical Research Networking Center in Oncology (CIBERONC), Madrid, 28029, Spain.
⁷ Department of Pathology, Fundación Jiménez Díaz University Hospital Health Research Institute, Madrid, 28040, Spain.
⁸ Department of Clinical Oncology, University Clinical Hospital of Valencia, Valencia, 46010, Spain.
⁹ Department of Medicine, University of Valencia, Valencia, 46010, Spain.
¹⁰ Department of Physiology, University of Valencia, Valencia, 46010, Spain.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

ATP Binding Cassette Transporter, Subfamily G, Member 2 / genetics
Cyclooxygenase 2
Doxorubicin / pharmacology
Gene Expression Regulation, Neoplastic
Humans
MicroRNAs* / genetics
Neoplasm Proteins
Triple Negative Breast Neoplasms* / drug therapy
Triple Negative Breast Neoplasms* / genetics

Substances

Cyclooxygenase 2
MicroRNAs
Doxorubicin
ABCG2 protein, human
ATP Binding Cassette Transporter, Subfamily G, Member 2
Neoplasm Proteins