Association of nighttime physical activity with all-cause and cardiovascular mortality: Results from the NHANES

Jiayi Yi; Lili Wang; Jiajun Guo; Ping Sun; Ping Shuai; Xiaoxiang Ma; Xiaojiao Zuo; Yuping Liu; Zhengwei Wan

doi:10.3389/fcvm.2022.918996

Association of nighttime physical activity with all-cause and cardiovascular mortality: Results from the NHANES

Front Cardiovasc Med. 2022 Aug 5:9:918996. doi: 10.3389/fcvm.2022.918996. eCollection 2022.

Authors

Jiayi Yi¹, Lili Wang¹, Jiajun Guo², Ping Sun^{3

4}, Ping Shuai^{3

4}, Xiaoxiang Ma³, Xiaojiao Zuo³, Yuping Liu^{3

4}, Zhengwei Wan^{3

4}

Affiliations

¹ Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
² Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
³ Department of Health Management & Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
⁴ Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.

Abstract

Background: Nighttime physical activity (PA) has significant effects on human health. Whether excessive nighttime PA is associated with adverse long-term prognosis remains unknown.

Methods: Three thousand six hundred ninety adults from the US National Health and Nutrition Examination Survey (NHANES) 2003-2006 with accelerometer monitor recording PA data were included. Nighttime PA was quantified by the nighttime to all-day PA intensity ratio (NAPAIR). Participants with the NAPAIR above the population median (0.17) were defined as the nighttime active population (NAP), otherwise as the daytime active population. All-cause and cardiovascular disease mortality status was acquired from the US National Death Index from their interview and physical examination date through December 31, 2015.

Results: Among 3690 adults (weighted mean age 48.1 years), 1781 (weighted proportion 48.8%) were females. One thousand eight hundred six (48.9%) were determined as the NAP. During the follow-up period of up to 13.1 years (median, 10.7 years), 639 deaths occurred (heart diseases, 114). Multivariable Cox proportional hazards model showed that the NAP was associated with higher risks of all-cause (hazard ratio [HR], 1.46; 95% confidence interval [CI], 1.22-1.75) and cardiovascular disease (HR, 1.58; 95% CI, 1.03-2.41) mortality compared with the daytime active population, and each 0.1 increase in the NAPAIR was associated with 15% increased all-cause mortality risks.

Conclusion: In this nationally representative prospective cohort study of a sample of United States adults, excessive nighttime PA was associated with a higher risk of death from all causes and cardiovascular disease.

Keywords: National Health and Nutrition Examination Survey (NHANES); all-cause mortality; cardiovascular mortality; nighttime; physical activities.