Real-time optical oximetry during FLASH radiotherapy using a phosphorescent nanoprobe

Byunghang Ha; Kaitlyn Liang; Cheng Liu; Stavros Melemenidis; Rakesh Manjappa; Vignesh Viswanathan; Neeladrisingha Das; Ramish Ashraf; Brianna Lau; Luis Soto; Edward E Graves; Jianghong Rao; Billy W Loo Jr; Guillem Pratx

doi:10.1016/j.radonc.2022.08.011

Real-time optical oximetry during FLASH radiotherapy using a phosphorescent nanoprobe

Radiother Oncol. 2022 Nov:176:239-243. doi: 10.1016/j.radonc.2022.08.011. Epub 2022 Aug 11.

Authors

Affiliations

¹ Department of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA; Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
² Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA; Department of Applied Physics, Stanford University, Stanford, CA 94305, USA.
³ Molecular Imaging Program at Stanford, Departments of Radiology and Chemistry, Stanford University, Stanford, CA 94305, USA.
⁴ Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.
⁵ Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA. Electronic address: pratx@stanford.edu.

Abstract

The rapid depletion of oxygen during irradiation at ultra-high dose rate calls for tissue oximeters capable of high temporal resolution. This study demonstrates a water-soluble phosphorescent nanoprobe and fiber-coupled instrument, which together are used to measure the kinetics of oxygen depletion at 200 Hz during irradiation of in vitro solutions.

Keywords: FLASH radiotherapy; Nanoparticles; Oximetry; Oxygen; Phosphorimetry.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Humans
Oximetry*
Oxygen*
Radiotherapy
Radiotherapy Dosage

Substances

Oxygen

Abstract

Publication types

MeSH terms

Substances

Grants and funding