Inflammatory profile and white matter hyperintensity burden in acute ischemic stroke patients

J Neuroimmunol. 2022 Oct 15:371:577934. doi: 10.1016/j.jneuroim.2022.577934. Epub 2022 Jul 29.

Abstract

Inflammation is involved in small vessel disease (SVD). We aim to clarify whether inflammation related to white matter hyperintensities (WMH), a key component of SVD, may affect the inflammatory response in acute ischemic stroke (AIS) patients. For this, we sequentially measured 10 circulating inflammatory markers and assessed WMH burden on admission MRI in AIS patients treated with thrombectomy. Of 149 patients, 57 (38.3%) had a high WMH burden (Fazekas≥3). A high WMH burden was associated with 4 markers levels but this association did not remain following multivariable analyses. WMH burden is not associated with a specific inflammatory profile in AIS.

Keywords: Blood biomarkers; Cerebral small vessel diseases; Inflammation; Reperfusion injury; Stroke; Thrombectomy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers
  • Brain Ischemia* / complications
  • Brain Ischemia* / diagnostic imaging
  • Humans
  • Inflammation / complications
  • Inflammation / diagnostic imaging
  • Ischemic Stroke* / diagnostic imaging
  • Magnetic Resonance Imaging
  • Stroke* / complications
  • Stroke* / diagnostic imaging
  • White Matter* / diagnostic imaging

Substances

  • Biomarkers