The urgent need to improve childhood cancer cachexia

Daniel V Runco; Teresa A Zimmers; Andrea Bonetto

doi:10.1016/j.trecan.2022.07.005

The urgent need to improve childhood cancer cachexia

Trends Cancer. 2022 Dec;8(12):976-979. doi: 10.1016/j.trecan.2022.07.005. Epub 2022 Aug 3.

Authors

Daniel V Runco¹, Teresa A Zimmers², Andrea Bonetto³

Affiliations

¹ Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children at IU Health, Indianapolis, IN, USA; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: drunco@iupui.edu.
² Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Otolaryngology - Head & Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA; Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA.
³ Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Otolaryngology - Head & Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: andrea.bonetto@cuanschutz.edu.

Abstract

Clinical care and research around cancer cachexia in children is lacking. Cachexia increases treatment-related toxicity and long-term morbidity and potentially affects mortality. We highlight the urgent need for specific focus on childhood cancer cachexia and discuss potential solutions to inform cachexia therapeutics for children.

Keywords: animal models; cachexia; cancer treatments; inflammation; metabolism; nutrition; pediatric.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Cachexia* / etiology
Cachexia* / therapy
Child
Humans
Neoplasms* / complications

Abstract

Publication types

MeSH terms

Grants and funding