The neutrophil-to-lymphocyte ratio is associated with intubation in pediatric anti-NMDA receptor encephalitis: A retrospective study

J Neuroimmunol. 2022 Sep 15:370:577931. doi: 10.1016/j.jneuroim.2022.577931. Epub 2022 Jul 15.

Abstract

Background The neutrophil-to-lymphocyte ratio (NLR) may predict poor outcomes in adult anti-NMDAR encephalitis (NMDARE). The association of NLR with outcomes in pediatric NMDARE was examined. Methods Pediatric NMDARE patients (N = 36) were retrospectively studied. Results High NLR (>6) had a higher proportion of tumors (43% versus 7%) and higher intubation rates (100% versus 38%, p = 0.008). Multivariate analyses showed that high NLR did not correlate with one-year outcomes, inpatient length of stay (LOS), or with tumor, but was associated with intubation and rehabilitation LOS. Conclusion NLR is associated with intubation and rehabilitation LOS. Further investigation is needed for prognostic biomarkers in NMDARE.

Keywords: Anti-NMDA receptor antibodies; Anti-NMDA receptor encephalitis; Autoimmune encephalitis; Neutrophil to lymphocyte ratio; Pediatric autoimmune encephalitis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-N-Methyl-D-Aspartate Receptor Encephalitis* / complications
  • Child
  • Humans
  • Intubation, Intratracheal
  • Lymphocytes
  • Neutrophils
  • Receptors, N-Methyl-D-Aspartate
  • Retrospective Studies

Substances

  • Receptors, N-Methyl-D-Aspartate