Associations between combined exposure to environmental hazards and social stressors at the neighborhood level and individual perinatal outcomes in the ECHO-wide cohort

Sheena E Martenies; Mingyu Zhang; Anne E Corrigan; Anton Kvit; Timothy Shields; William Wheaton; Theresa M Bastain; Carrie V Breton; Dana Dabelea; Rima Habre; Sheryl Magzamen; Amy M Padula; Deana Around Him; Carlos A Camargo Jr; Whitney Cowell; Lisa A Croen; Sean Deoni; Todd M Everson; Tina V Hartert; Alison E Hipwell; Cindy T McEvoy; Rachel Morello-Frosch; Thomas G O'Connor; Michael Petriello; Sheela Sathyanarayana; Joseph B Stanford; Tracey J Woodruff; Rosalind J Wright; Amii M Kress; program collaborators for Environmental influences on Child Health Outcomes

doi:10.1016/j.healthplace.2022.102858

Associations between combined exposure to environmental hazards and social stressors at the neighborhood level and individual perinatal outcomes in the ECHO-wide cohort

Health Place. 2022 Jul:76:102858. doi: 10.1016/j.healthplace.2022.102858. Epub 2022 Jul 21.

Authors

Sheena E Martenies¹, Mingyu Zhang², Anne E Corrigan², Anton Kvit², Timothy Shields², William Wheaton³, Theresa M Bastain⁴, Carrie V Breton⁴, Dana Dabelea⁵, Rima Habre⁴, Sheryl Magzamen⁶, Amy M Padula⁷, Deana Around Him⁸, Carlos A Camargo Jr⁹, Whitney Cowell¹⁰, Lisa A Croen¹¹, Sean Deoni¹², Todd M Everson¹³, Tina V Hartert¹⁴, Alison E Hipwell¹⁵, Cindy T McEvoy¹⁶, Rachel Morello-Frosch¹⁷, Thomas G O'Connor¹⁸, Michael Petriello¹⁹, Sheela Sathyanarayana²⁰, Joseph B Stanford²¹, Tracey J Woodruff⁷, Rosalind J Wright²², Amii M Kress²; program collaborators for Environmental influences on Child Health Outcomes

Affiliations

¹ University of Illinois at Urbana-Champaign, USA. Electronic address: smarte4@illinois.edu.
² Johns Hopkins University, USA.
³ Research Triangle Institute, USA.
⁴ University of Southern California, USA.
⁵ University of Colorado Anschutz Medical Campus, USA.
⁶ Colorado State University, USA.
⁷ University of California San Francisco, USA.
⁸ Child Trends, USA.
⁹ Massachusetts General Hospital, USA.
¹⁰ New York University, USA.
¹¹ Kaiser Permanente Northern California Division of Research, USA.
¹² Brown University, USA.
¹³ Rollins School of Public Health at Emory University, USA.
¹⁴ Vanderbilt University School of Medicine, USA.
¹⁵ University of Pittsburgh, USA.
¹⁶ Oregon Health & Science University, USA.
¹⁷ University of California Berkeley, USA.
¹⁸ University of Rochester Medical Center, Rochester, NY, USA.
¹⁹ Wayne State University, Institute of Environmental Health Sciences, USA.
²⁰ University of Washington, Seattle Children's Research Institute, USA.
²¹ University of Utah, Departments of Family and Preventive Medicine and Pediatrics, USA.
²² Icahn School of Medicine at Mount Sinai, USA.

Abstract

Limited studies examine how prenatal environmental and social exposures jointly impact perinatal health. Here we investigated relationships between a neighborhood-level combined exposure (CE) index assessed during pregnancy and perinatal outcomes, including birthweight, gestational age, and preterm birth. Across all participants, higher CE index scores were associated with small decreases in birthweight and gestational age. We also observed effect modification by race; infants born to Black pregnant people had a greater risk of preterm birth for higher CE values compared to White infants. Overall, our results suggest that neighborhood social and environmental exposures have a small but measurable joint effect on neonatal indicators of health.

Keywords: Environmental hazards; Neighborhoods; Perinatal health; Prenatal; Social stressors.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Birth Weight
Cohort Studies
Female
Gestational Age
Humans
Infant
Infant, Newborn
Pregnancy
Premature Birth* / epidemiology

Abstract

Publication types

MeSH terms

Grants and funding