A shattering experience

Mol Cell. 2022 Jul 7;82(13):2360-2362. doi: 10.1016/j.molcel.2022.06.018.

Abstract

Tang et al. (2022) report that the DNA breaks that provoke chromothripsis-the pulverization and dramatic assembly into a rearranged chromosome-are generated by the base excision repair APE1 endonuclease, triggered by removing deoxyinosines that are created in DNA::RNA hybrids.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Chromothripsis*
  • DNA / genetics
  • DNA Damage
  • DNA Repair*
  • Humans

Substances

  • DNA