GuitarPD: A Randomized Pilot Study on the Impact of Nontraditional Guitar Instruction on Functional Movement and Well-Being in Parkinson's Disease

Serap Bastepe-Gray; Lavinia Wainwright; Diane C Lanham; Gabriela Gomez; Jieung S Kim; Zane Forshee; Bonnie Kaas; Arita McCoy; Colin McGregor; Emile Moukheiber; Suraj Rajan; Gerson Suarez-Cedeno; Jiangxia Wang; Sean Brennan; Shane Coughlin; Kyurim Kang; Alexander Pantelyat

doi:10.1155/2022/1061045

GuitarPD: A Randomized Pilot Study on the Impact of Nontraditional Guitar Instruction on Functional Movement and Well-Being in Parkinson's Disease

Parkinsons Dis. 2022 Jun 25:2022:1061045. doi: 10.1155/2022/1061045. eCollection 2022.

Authors

Serap Bastepe-Gray^{1

2}, Lavinia Wainwright¹, Diane C Lanham¹, Gabriela Gomez¹, Jieung S Kim¹, Zane Forshee², Bonnie Kaas¹, Arita McCoy¹, Colin McGregor¹, Emile Moukheiber¹, Suraj Rajan¹, Gerson Suarez-Cedeno¹, Jiangxia Wang³, Sean Brennan², Shane Coughlin², Kyurim Kang¹, Alexander Pantelyat¹

Affiliations

¹ Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
² Peabody Conservatory, Johns Hopkins University Peabody Institute, Baltimore, MD, USA.
³ Department of Biostatistics, Johns Hopkins University School of Public Health Biostatistics Center, Baltimore, MD, USA.

Abstract

Playing musical instruments may have positive effects on motor, emotional, and cognitive deficits in patients with Parkinson's disease (PD). This pilot study examined the feasibility of a six-week nontraditional guitar instruction program for individuals with PD. Twenty-six participants with idiopathic PD (Age: 67.22 ± 8.07; 17 males) were randomly assigned to two groups (intervention first or 6 weeks of usual care control exposure) with stepwise exposure to the guitar intervention condition with cross-over at six weeks. Outcomes were assessed at baseline, 6, 12, and 18 weeks. Twenty-four participants completed the study. Combined analysis of the groups showed significant BDI-II improvement immediately after intervention completion (3.04 points, 95% CI [-5.2, -0.9], p = 0.04). PDQ-39 total quality of life scores improved from baseline to immediately postintervention 5.19 points (95% CI [-9.4, -1.0]) at trend significance (corrected p = 0.07). For Group 1 (exposed to the intervention first), MDS-UPDRS total scores improved by a mean of 8.04 points (95% CI [-12.4, -3.7], p = 0.004) and remained improved at 12 weeks by 10.37 points (95% CI [-14.7, -6.0], p < 0.001). This group also had significant improvements in mood and depression at weeks 6 and 12, remaining significant at week 18 (BDI-II: 3.75, 95% CI [-5.8, -1.7], p = 0.004; NeuroQoL-depression: 10.6, 95% CI [-4.9. -1.4], p = 0.004), and in anxiety at week 6 and week 18 (NeuroQoL; 4.42, 95% CI [-6.8, -2.1], p = 0.004; 3.58, 95% CI [-5.9, -1.2], p = 0.02, respectively). We found clinically and statistically significant improvements in mood/anxiety after 6 weeks of group guitar classes in individuals with PD. Group guitar classes can be a feasible intervention in PD and may improve mood, anxiety, and quality of life.