Ten-Gram-Scale Mechanochemical Synthesis of Ternary Lanthanum Coordination Polymers for Antibacterial and Antitumor Activities

Liying Zhang; Haoran Shi; Xiao Tan; Zhenqi Jiang; Ping Wang; Jieling Qin

doi:10.3389/fchem.2022.898324

Ten-Gram-Scale Mechanochemical Synthesis of Ternary Lanthanum Coordination Polymers for Antibacterial and Antitumor Activities

Front Chem. 2022 Jun 14:10:898324. doi: 10.3389/fchem.2022.898324. eCollection 2022.

Authors

Liying Zhang¹, Haoran Shi¹, Xiao Tan², Zhenqi Jiang³, Ping Wang^{1

2}, Jieling Qin^{1

2}

Affiliations

¹ School of Life Sciences and Medicine, Shandong University of Technology, Zibo, China.
² Tongji University Cancer Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
³ Institute of Engineering Medicine, Beijing Institute of Technology, Beijing, China.

Abstract

As rare-earth coordination polymers (CPs) have appreciable antimicrobial properties, ternary lanthanum CPs have been widely synthesized and investigated in recent years. Here, we report convenient, solvent-free reactions between the lanthanum salt and two ligands at mild temperatures that form ternary lanthanum nanoscale CPs with 10-gram-scale. The structural features and morphologies were characterized using a scanning electron microscope (SEM), Fourier transform infrared spectrometer (FT-IR), ultraviolet-visible (UV-Vis), X-ray diffractometer (XRD), X-ray Photoelectron Spectroscopy (XPS), Brunauer-Emmett-Teller (BET), elemental analysis, inductively coupled plasma mass spectrometry (ICP-MS), electrospray ionization mass spectrometry (ESI-MS), nuclear magnetic resonance (NMR), dynamic light scattering (DLS) and analyzer, and thermogravimetric and differential thermal analyzer (TG-DTA). Furthermore, the in vitro antibacterial activities of these ternary hybrids were studied using the zone of inhibition (ZOI) method, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and transmission electron microscope (TEM) and were found to have excellent antibacterial properties. The in vitro antitumor activities were performed in determining the absorbance values by CCK-8 (Cell Counting Kit-8) assay. This facile synthetic method would potentially enable the mass production of ternary lanthanum CPs at room temperature, which can be promising candidates as antibacterial compounds and antitumor agents.

Keywords: antibacterial performance; antitumor activities; coordination polymers; lanthanum hybrids; solid-state reaction.