Emerging role of LINC00461 in cancer

Qiudan Zhang; Chenming Zhong; Jinze Shen; Sang Chen; Yunhua Jia; Shiwei Duan

doi:10.1016/j.biopha.2022.113239

Emerging role of LINC00461 in cancer

Biomed Pharmacother. 2022 Aug:152:113239. doi: 10.1016/j.biopha.2022.113239. Epub 2022 Jun 6.

Authors

Qiudan Zhang¹, Chenming Zhong², Jinze Shen³, Sang Chen², Yunhua Jia⁴, Shiwei Duan⁵

Affiliations

¹ Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, China; Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China.
² Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China.
³ Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, China.
⁴ Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, China. Electronic address: jiayh@zucc.edu.cn.
⁵ Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, Zhejiang 310015, China. Electronic address: duansw@zucc.edu.cn.

PMID: 35679722
DOI: 10.1016/j.biopha.2022.113239

Abstract

LINC00461 is located in the intergenic region between the protein-coding genes MEF2C and TMEM161B. LINC00461 upregulation was associated with the risk of 13 tumors and was strongly associated with clinicopathologic features and poor prognosis in 11 tumors. LINC00461 is involved in resistance to four anticancer drugs, including sunitinib for renal cell carcinoma, cisplatin for head and neck squamous cell carcinoma and rectal cancer, temozolomide for glioma, and docetaxel for breast cancer. LINC00461 can sponge 18 miRNAs to form a complex ceRNA network that regulates the expression of a large number of downstream genes. LINC00461 is involved in the MAPK/ERK signaling pathway and PI3K/AKT signaling pathway, thereby promoting tumorigenesis. Notably, knockdown of LINC00461 in exosomes antagonizes tumor cell proliferation in multiple myeloma. This article summarizes the diagnostic, prognostic, and therapeutic value of LINC00461 in various tumors, and systematically describes the ceRNA network and signaling pathways associated with LINC00461, providing potential directions for future LINC00461 research.

Keywords: Cancer; Competing endogenous RNA; Diagnosis; Drug resistance; LINC00461; Prognosis.

Publication types

Review

MeSH terms

Carcinoma, Renal Cell* / genetics
Gene Expression Regulation, Neoplastic
Humans
Kidney Neoplasms* / genetics
MicroRNAs* / genetics
Phosphatidylinositol 3-Kinases / metabolism
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism

Substances

MicroRNAs
RNA, Long Noncoding