Selection and structural bases of potent broadly neutralizing antibodies from 3-dose vaccinees that are highly effective against diverse SARS-CoV-2 variants, including Omicron sublineages

Lei Wang; Wangjun Fu; Linlin Bao; Zijing Jia; Yuxia Zhang; Yunjiao Zhou; Wei Wu; Jianbo Wu; Qianqian Zhang; Yidan Gao; Kang Wang; Qiao Wang; Chuan Qin; Xiangxi Wang

doi:10.1038/s41422-022-00677-z

Selection and structural bases of potent broadly neutralizing antibodies from 3-dose vaccinees that are highly effective against diverse SARS-CoV-2 variants, including Omicron sublineages

Cell Res. 2022 Jul;32(7):691-694. doi: 10.1038/s41422-022-00677-z. Epub 2022 Jun 7.

Authors

Lei Wang^#^{1

2}, Wangjun Fu^#^{1

2}, Linlin Bao^#³, Zijing Jia^#^{1

2}, Yuxia Zhang^#⁴, Yunjiao Zhou^#⁵, Wei Wu⁵, Jianbo Wu⁵, Qianqian Zhang⁵, Yidan Gao⁵, Kang Wang^{1

2}, Qiao Wang⁶, Chuan Qin⁷, Xiangxi Wang^{8

9

10}

Affiliations

¹ CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
² University of Chinese Academy of Sciences, Beijing, China.
³ Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China.
⁴ Changping Laboratory, Beijing, China.
⁵ Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
⁶ Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China. wangqiao@fudan.edu.cn.
⁷ Key Laboratory of Human Disease Comparative Medicine, Chinese Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing, China. qinchuan@pumc.edu.cn.
⁸ CAS Key Laboratory of Infection and Immunity, National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. xiangxi@ibp.ac.cn.
⁹ University of Chinese Academy of Sciences, Beijing, China. xiangxi@ibp.ac.cn.
¹⁰ Changping Laboratory, Beijing, China. xiangxi@ibp.ac.cn.

^# Contributed equally.

No abstract available

Publication types

Letter

MeSH terms

Antibodies, Neutralizing
Antibodies, Viral
Broadly Neutralizing Antibodies
COVID-19*
Humans
SARS-CoV-2*
Spike Glycoprotein, Coronavirus / genetics

Substances

Antibodies, Neutralizing
Antibodies, Viral
Broadly Neutralizing Antibodies
Spike Glycoprotein, Coronavirus
spike protein, SARS-CoV-2

Supplementary concepts

SARS-CoV-2 variants