Toxicity studies of select ionic liquids (1-ethyl-3-methylimidazolium chloride, 1-butyl-3-methylimidazolium chloride, 1-butyl-1-methylpyrrolidinium chloride, and n-butylpyridinium chloride) administered in drinking water to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice

National Toxicology Program

doi:10.22427/NTP-TOX-103

Toxicity studies of select ionic liquids (1-ethyl-3-methylimidazolium chloride, 1-butyl-3-methylimidazolium chloride, 1-butyl-1-methylpyrrolidinium chloride, and n-butylpyridinium chloride) administered in drinking water to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice

Toxic Rep Ser. 2022 May:(103):NTP-TOX-103. doi: 10.22427/NTP-TOX-103.

Author

National Toxicology Program¹

Collaborators

National Toxicology Program:
R A Dee, K R Ryan, S A Elmore, K L Aillon, J W Algaier, T P Arndt, B Astroff, C R Blystone, M A Buccellato, B L Burback, M F Cesta, K Y Cimon, A P Clark, P S Clemons, P S Coder, D A Contos, J Cookinham, M C Cora, H C Cunny, R H Elbekai, J M Fostel, R P Frawley, D R Germolec, C A Granville, S W Graves, S J Harbo, M R Hejtmancik, M J Hooth, A Kazerooni, A P King-Herbert, K A B Knostman, A J Mainey, D E Malarkey, B S McIntyre, D Messer, E Mutlu, E Mylchreest, B O'Brien, M Paranjpe, K M Patton, J S Richey, G K Roberts, M Roth, M J Ryan, K E Schnare, K E Setty, S A Shah, K A Shipkowski, K R Shockley, L Siemann, A J Skowronek, N L South, B R Sparrow, M D Stout, G S Travlos, S Waidyanatha, N J Walker, M L Wenk, K L Witt, A M Zmarowski

Affiliation

¹ Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

Abstract

Ionic liquids (ILs) are synthetic solvents with applications in a variety of industrial and chemical industries. Human exposure to this diverse chemical class is primarily through dermal or oral routes. Research suggests toxicity may be associated with IL structural characteristics, including the type of cation base or alkyl chain substitutions associated with the cation. To further investigate this hypothesis, the National Toxicology Program (NTP) conducted 3-month toxicity studies in male and female Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice (n = 10/sex/exposure group; 3 exposure concentrations per IL) to compare the relative toxicities of four ILs administered via drinking water-1-ethyl-3-methylimidazolium chloride (Emim-Cl), 1-butyl-3-methylimidazolium chloride (Bmim-Cl), 1-butyl-1-methylpyrrolidinium chloride (Bmpy-Cl), and n-butylpyridinium chloride (NBuPy-Cl). (Abstract Abridged).

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