Malondialdehyde value as radical oxidative marker and endogenous antioxidant value analysis in brain tumor

Ridha Dharmajaya; Dina Keumala Sari

doi:10.1016/j.amsu.2021.103231

Malondialdehyde value as radical oxidative marker and endogenous antioxidant value analysis in brain tumor

Ann Med Surg (Lond). 2022 Mar 23:77:103231. doi: 10.1016/j.amsu.2021.103231. eCollection 2022 May.

Authors

Ridha Dharmajaya¹, Dina Keumala Sari²

Affiliations

¹ Department of Neurosurgery, Faculty of Medicine Universitas Sumatera Utara, Medan, Indonesia.
² Department of Nutrition, Faculty of Medicine Universitas Sumatera Utara, Medan, Indonesia.

Abstract

Introduction: Oxidative stress has been considered as one of many contributor in developing risk of cancer. Oxidative stress may also promote the increasing number of free radical. Malondialdehyde (MDA) is one of radical oxidative marker, while Superoxide Dismutase (SOD) play role as endogenous antioxidant. It has been postulated that in cancer cells there is an increase of oxidative stress compared to normal cell.

Method: This study is a case controlled analytical study to find the relationship between levels of MDA and SOD in patients with brain tumours. The sample obtained was 35 people who met the inclusion and exclusion criteria. Based on this analysis, it will be determined whether there is a significant relationship between levels of MDA and SOD in each type of brain tumours.

Result: There is no significant relationship from all groups brain tumour and all tumours have a low correlation (r = 0.187) in the value of superoxide dismutase level. There is also no significant relationship from all groups (p = 0.302) and a low correlation (r = 0.187) to the value of Malondialdehyde level.

Discussion: There was no relationship between superoxide dismutase in any type of intracranial tumour in this study. These concluded that superoxide values could not be a risk factor for primary intracranial tumours. Levels of MDA which is an indicator of lipid peroxidation, were significantly higher in patients consisting of meningiomas and gliomas. In high grade gliomas, the MDA increases due to the progressive progression of glioma tumours due to an increase in Reactive oxygen species levels.

Conclusion: This study shows no correlation between SOD as an endogenous antioxidant and MDA as radical oxidative marker in primary brain tumour.

Keywords: Brain tumour; Endogenous antioxidant; Malondialdehyde; Neurooncology; Superoxide dismutase.