SARS-CoV-2 Virology

Yijia Li; Jonathan Z Li

doi:10.1016/j.idc.2022.01.004

SARS-CoV-2 Virology

Infect Dis Clin North Am. 2022 Jun;36(2):251-265. doi: 10.1016/j.idc.2022.01.004. Epub 2022 Jan 31.

Authors

Yijia Li¹, Jonathan Z Li²

Affiliations

¹ Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
² Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: jli@bwh.harvard.edu.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in 2020 and has led to an unprecedented global pandemic. Understanding the virology behind SARS-CoV-2 infection has provided key insights into our efforts to develop antiviral agents and control the COVID-19 pandemic. In this review, the authors focus on the genomic features of SARS-CoV-2, its intrahost and interhost evolution, viral dynamics in respiratory tract, and systemic dissemination.

Keywords: COVID-19; Monoclonal antibody; Receptor-binding domain; SARS-CoV-2; Viremia.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Antiviral Agents / therapeutic use
COVID-19*
Humans
Pandemics
SARS-CoV-2*

Substances

Antiviral Agents

Grants and funding

P30 AI060354/AI/NIAID NIH HHS/United States