Ceftazidime-Avibactam in Combination with Imipenem as Salvage Therapy for ST11 KPC-33-Producing Klebsiella pneumoniae

Li Ding; Siquan Shen; Renru Han; Dandan Yin; Yan Guo; Fupin Hu

doi:10.3390/antibiotics11050604

Ceftazidime-Avibactam in Combination with Imipenem as Salvage Therapy for ST11 KPC-33-Producing Klebsiella pneumoniae

Antibiotics (Basel). 2022 Apr 29;11(5):604. doi: 10.3390/antibiotics11050604.

Authors

Li Ding^{1

2}, Siquan Shen^{1

2}, Renru Han^{1

2}, Dandan Yin^{1

2}, Yan Guo^{1

2}, Fupin Hu^{1

2}

Affiliations

¹ Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China.
² Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai 200040, China.

Abstract

A 22-year-old man, after a hematopoietic stem cell transplant, suffered long-term pneumonia caused by bla_KPC-2-positive K. pneumoniae and bla_KPC-33-positive K. pneumoniae alternately and finally achieved pathogenic clearance and improvement of clinical infectious conditions after using ceftazidime-avibactam in combination with imipenem as salvage therapy. This case provides a reference for treating infection caused by K. pneumoniae with a KPC variant in countries lacking new antimicrobial agents.

Keywords: KPC-2; KPC-33; ceftazidime–avibactam; imipenem.

Publication types

Case Reports

Abstract

Publication types

Grants and funding