Proceedings from the Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Immune and Cellular Therapy in Multiple Myeloma

Sarah A Holstein; Fotis Asimakopoulos; Abdel Kareem Azab; Giada Bianchi; Manisha Bhutani; Leslie A Crews; Tom Cupedo; Hannah Giles; Sarah Gooding; Jens Hillengass; Lukas John; Shari Kaiser; Lydia Lee; Kylee Maclachlan; Marcelo C Pasquini; Flavia Pichiorri; Nina Shah; Monica Shokeen; Brian R Shy; Eric L Smith; Raluca Verona; Saad Z Usmani; Philip L McCarthy

doi:10.1016/j.jtct.2022.05.019

Proceedings from the Blood and Marrow Transplant Clinical Trials Network Myeloma Intergroup Workshop on Immune and Cellular Therapy in Multiple Myeloma

Transplant Cell Ther. 2022 Aug;28(8):446-454. doi: 10.1016/j.jtct.2022.05.019. Epub 2022 May 21.

Authors

Sarah A Holstein¹, Fotis Asimakopoulos², Abdel Kareem Azab³, Giada Bianchi⁴, Manisha Bhutani⁵, Leslie A Crews², Tom Cupedo⁶, Hannah Giles⁷, Sarah Gooding⁸, Jens Hillengass⁹, Lukas John¹⁰, Shari Kaiser¹¹, Lydia Lee¹², Kylee Maclachlan¹³, Marcelo C Pasquini¹⁴, Flavia Pichiorri¹⁵, Nina Shah¹⁶, Monica Shokeen³, Brian R Shy¹⁶, Eric L Smith¹⁷, Raluca Verona¹⁸, Saad Z Usmani¹³, Philip L McCarthy⁹

Affiliations

¹ University of Nebraska Medical Center, Omaha, Nebraska. Electronic address: sarah.holstein@unmc.edu.
² Moores Cancer Center, University of California San Diego, La Jolla, California.
³ Washington University School of Medicine, St. Louis, Missouri.
⁴ Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
⁵ Levine Cancer Institute, Charlotte, North Carolina.
⁶ ErasmusMC Cancer Institute Rotterdam, Rotterdam, The Netherlands.
⁷ University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.
⁸ MRC Molecular Hematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.
⁹ Roswell Park Comprehensive Cancer Center, Buffalo, New York.
¹⁰ University Hospital Heidelberg, Heidelberg, Germany.
¹¹ Bristol Myers Squibb, Seattle, Washington.
¹² University College London, London, United Kingdom.
¹³ Memorial Sloan Kettering Cancer Center, New York, New York.
¹⁴ Medical College of Wisconsin, Milwaukee, Wisconsin.
¹⁵ Judy and Bernard Briskin Center for Multiple Myeloma Research, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California; Department of Hematologic Malignancies Translational Science, Beckman Research Institute, City of Hope, Duarte, California.
¹⁶ University of California San Francisco, San Francisco, California.
¹⁷ Dana-Farber Cancer Institute, Boston, Massachusetts.
¹⁸ Janssen Research & Development, Spring House, Pennsylvania.

Abstract

The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) Myeloma Intergroup conducted a workshop on Immune and Cellular Therapy in Multiple Myeloma on January 7, 2022. This workshop included presentations by basic, translational, and clinical researchers with expertise in plasma cell dyscrasias. Four main topics were discussed: platforms for myeloma disease evaluation, insights into pathophysiology, therapeutic target and resistance mechanisms, and cellular therapy for multiple myeloma. Here we provide a comprehensive summary of these workshop presentations.

Keywords: CAR T cell; Imaging; Multiple myeloma; Resistance; Tumor microenvironment.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Bone Marrow
Cell- and Tissue-Based Therapy
Clinical Trials as Topic
Humans
Multiple Myeloma* / therapy

Abstract

Publication types

MeSH terms

Grants and funding