Polygenic risk scores for CARDINAL study

Clement A Adebamowo; Adebowale Adeyemo; Adeyinka Ashaye; Onoja M Akpa; Tinashe Chikowore; Ananyo Choudhury; Yasmina J Fakim; Segun Fatumo; Neil Hanchard; Michael Hauser; Braxton Mitchell; Nicola Mulder; Solomon F Ofori-Acquah; Mayowa Owolabi; Michèle Ramsay; Bamidele Tayo; Archana Bhavani VasanthKumar; Yuji Zhang; Sally N Adebamowo

doi:10.1038/s41588-022-01074-3

Polygenic risk scores for CARDINAL study

Nat Genet. 2022 May;54(5):527-530. doi: 10.1038/s41588-022-01074-3.

Authors

Clement A Adebamowo^{1

2}, Adebowale Adeyemo³, Adeyinka Ashaye⁴, Onoja M Akpa⁵, Tinashe Chikowore⁶, Ananyo Choudhury⁶, Yasmina J Fakim⁷, Segun Fatumo^{8

9}, Neil Hanchard³, Michael Hauser¹⁰, Braxton Mitchell¹¹, Nicola Mulder¹², Solomon F Ofori-Acquah^{13

14}, Mayowa Owolabi¹⁵, Michèle Ramsay⁶, Bamidele Tayo¹⁶, Archana Bhavani VasanthKumar¹, Yuji Zhang^{2

17}, Sally N Adebamowo^{18

19}

Affiliations

¹ Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
² University of Maryland Marlene and Stewart Greenbaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
³ National Human Genome Research Institute, Rockville, MD, USA.
⁴ Department of Ophthalmology, University of Ibadan, Ibadan, Nigeria.
⁵ Department of Epidemiology and Medical Statistics, University of Ibadan, Ibadan, Nigeria.
⁶ Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
⁷ Department of Biotechnology, University of Mauritius, Reduit, MU, Mauritius.
⁸ The African Computational Genomics (TACG) Research Group, MRC/UVRI and LSHTM (Uganda Research Unit), Entebbe, Uganda.
⁹ London School of Hygiene and Tropical Medicine, London, UK.
¹⁰ Department of Medicine, Duke University, Durham, NC, USA.
¹¹ Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
¹² Computational Biology Division, IDM, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
¹³ West African Genetic Medicine Centre (WAGMC), University of Ghana, Accra, Ghana.
¹⁴ Center for Translational and International Hematology, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.
¹⁵ Department of Medicine and Center for Genomic and Precision Medicine, University of Ibadan, Ibadan, Nigeria.
¹⁶ Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA.
¹⁷ Division of Biostatistics and Bioinformatics, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
¹⁸ Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA. sadebamowo@som.umaryland.edu.
¹⁹ University of Maryland Marlene and Stewart Greenbaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA. sadebamowo@som.umaryland.edu.

Abstract

The Cardiometabolic Disorders in African-Ancestry Populations (CARDINAL) study site is a well-powered, first-of-its-kind resource for developing, refining and validating methods for research into polygenic risk scores that accounts for local ancestry, to improve risk prediction in diverse populations.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Genetic Predisposition to Disease
Genome-Wide Association Study*
Humans
Multifactorial Inheritance* / genetics
Risk Factors

Abstract

Publication types

MeSH terms

Grants and funding