Krebs takes a turn at cell differentiation

Cell Metab. 2022 May 3;34(5):658-660. doi: 10.1016/j.cmet.2022.04.005.

Abstract

In a recent issue of Nature, Arnold et al. report that the partitioning of citrate away from the oxidative steps of the tricarboxylic acid cycle and into the citrate-malate shuttle is essential for mouse embryonic stem cell differentiation. Their findings highlight a crucial role for metabolic regulation in developmental biology.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Differentiation
  • Citrates* / metabolism
  • Citric Acid
  • Citric Acid Cycle*
  • Mice
  • Oxidation-Reduction

Substances

  • Citrates
  • Citric Acid