International League Against Epilepsy classification and definition of epilepsy syndromes with onset at a variable age: position statement by the ILAE Task Force on Nosology and Definitions

Kate Riney; Alicia Bogacz; Ernest Somerville; Edouard Hirsch; Rima Nabbout; Ingrid E Scheffer; Sameer M Zuberi; Taoufik Alsaadi; Satish Jain; Jacqueline French; Nicola Specchio; Eugen Trinka; Samuel Wiebe; Stéphane Auvin; Leonor Cabral-Lim; Ansuya Naidoo; Emilio Perucca; Solomon L Moshé; Elaine C Wirrell; Paolo Tinuper

doi:10.1111/epi.17240

International League Against Epilepsy classification and definition of epilepsy syndromes with onset at a variable age: position statement by the ILAE Task Force on Nosology and Definitions

Epilepsia. 2022 Jun;63(6):1443-1474. doi: 10.1111/epi.17240. Epub 2022 May 3.

Authors

Kate Riney^{1

2}, Alicia Bogacz³, Ernest Somerville^{4

5}, Edouard Hirsch^{6

7

8}, Rima Nabbout^{9

10

11}, Ingrid E Scheffer¹², Sameer M Zuberi^{11

13

14}, Taoufik Alsaadi¹⁵, Satish Jain¹⁶, Jacqueline French¹⁷, Nicola Specchio¹⁸, Eugen Trinka^{19

20

21}, Samuel Wiebe²², Stéphane Auvin^{23

24

25}, Leonor Cabral-Lim²⁶, Ansuya Naidoo^{27

28}, Emilio Perucca^{29

30}, Solomon L Moshé^{31

32}, Elaine C Wirrell³³, Paolo Tinuper^{34

35}

Affiliations

¹ Neurosciences Unit, Queensland Children's Hospital, South Brisbane, Queensland, Australia.
² Faculty of Medicine, University of Queensland, South Brisbane, Queensland, Australia.
³ Institute of Neurology, University of the Republic, Montevideo, Uruguay.
⁴ Prince of Wales Hospital, Sydney, New South Wales, Australia.
⁵ University of New South Wales, Sydney, New South Wales, Australia.
⁶ Francis Rohmer Epilepsy Unit, Hautepierre Hospital, Strasbourg, France.
⁷ National Institute of Health and Medical Research 1258, Strasbourg, France.
⁸ Federation of Translational Medicine of Strasbourg, University of Strasbourg, Strasbourg, France.
⁹ Reference Centre for Rare Epilepsies, Assistance Publique - Hôpitaux de Paris, Department of Pediatric Neurology, Necker-Enfants Malades Hospital, Member of Epicare, Paris, France.
¹⁰ Imagine Institute, National Institute of Health and Medical Research Mixed Unit of Research 1163, Paris, France.
¹¹ University City University, Paris, France.
¹² Austin Health, Royal Children's Hospital, Florey Institute and Murdoch Children's Research Institute, University of Melbourne, Melbourne, Victoria, Australia.
¹³ Paediatric Neurosciences Research Group, Royal Hospital for Children, Glasgow, UK.
¹⁴ Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.
¹⁵ Department of Neurology, American Center for Psychiatry and Neurology, Abu Dhabi, United Arab Emirates.
¹⁶ Indian Epilepsy Center, New Delhi, India.
¹⁷ New York University Grossman School of Medicine and NYU Langone Health, New York, New York, USA.
¹⁸ Rare and Complex Epilepsy Unit, Department of Neuroscience, Bambino Gesù Children's Hospital, Scientific Institute for Research and Health Care, member of EpiCARE, Rome, Italy.
¹⁹ Department of Neurology, Christian Doppler University Hospital, Paracelsus Medical University, Center for Cognitive Neuroscience, member of EpiCARE, Salzburg, Austria.
²⁰ Neuroscience Institute, Christian Doppler University Hospital, Center for Cognitive Neuroscience, Salzburg, Austria.
²¹ Department of Public Health, Health Services Research and Health Technology Assessment, University for Health Sciences, Medical Informatics, and Technology, Hall in Tirol, Austria.
²² Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
²³ Institut Universitaire de France, Paris, France.
²⁴ Paediatric Neurology, Assistance Publique - Hôpitaux de Paris, Robert-Debré Hospital, Paris, France.
²⁵ University of Paris, Paris, France.
²⁶ Department of Neurosciences, College of Medicine and Philippine General Hospital, Health Sciences Center, University of the Philippines Manila, Manila, the Philippines.
²⁷ Neurology Unit, Greys Hospital, Pietermaritzburg, South Africa.
²⁸ Department of Neurology, University of KwaZulu Natal, KwaZulu Natal, South Africa.
²⁹ Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia.
³⁰ Department of Neuroscience, Monash University, Melbourne, Victoria, Australia.
³¹ Isabelle Rapin Division of Child Neurology, Saul R. Korey Department of Neurology and Departments of Neuroscience and Pediatrics, Albert Einstein College of Medicine, New York, New York, USA.
³² Montefiore Medical Center, Bronx, New York, USA.
³³ Divisions of Child and Adolescent Neurology and Epilepsy, Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
³⁴ Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
³⁵ Reference Centre for Rare and Complex Epilepsies, IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy.

PMID: 35503725
DOI: 10.1111/epi.17240

Abstract

The goal of this paper is to provide updated diagnostic criteria for the epilepsy syndromes that have a variable age of onset, based on expert consensus of the International League Against Epilepsy Nosology and Definitions Taskforce (2017-2021). We use language consistent with current accepted epilepsy and seizure classifications and incorporate knowledge from advances in genetics, electroencephalography, and imaging. Our aim in delineating the epilepsy syndromes that present at a variable age is to aid diagnosis and to guide investigations for etiology and treatments for these patients.

Keywords: Rasmussen syndrome; epilepsy with reading-induced seizures; focal epilepsy syndromes; mesial temporal lobe epilepsy with hippocampal sclerosis; progressive myoclonus epilepsies.

MeSH terms

Advisory Committees
Electroencephalography / adverse effects
Epilepsy* / complications
Epilepsy* / diagnosis
Epileptic Syndromes* / complications
Humans
Seizures / diagnosis