Synthesis and in vitro anti-proliferative evaluation of naphthalimide-chalcone/pyrazoline conjugates as potential SERMs with computational validation

Shalini; Pankaj; Sourav Taru Saha; Mandeep Kaur; Ebenezer Oluwakemi; Paul Awolade; Parvesh Singh; Vipan Kumar

doi:10.1039/d0ra01822h

Synthesis and in vitro anti-proliferative evaluation of naphthalimide-chalcone/pyrazoline conjugates as potential SERMs with computational validation

RSC Adv. 2020 Apr 21;10(27):15836-15845. doi: 10.1039/d0ra01822h.

Authors

Shalini¹, Pankaj¹, Sourav Taru Saha², Mandeep Kaur², Ebenezer Oluwakemi³, Paul Awolade³, Parvesh Singh³, Vipan Kumar¹

Affiliations

¹ Department of Chemistry, Guru Nanak Dev University Amritsar 143005 India vipan_org@yahoo.com.
² School of Molecular and Cell Biology, University of Witwatersrand Private Bag 3, Wits-2050 Johannesberg South Africa mandeep.kaur@wits.ac.za.
³ School of Chemistry and Physics, University of Kwazulu Natal P/Bag X54001, Westville Durban 4000 South Africa.

Abstract

A series of naphthalimide-chalcone/pyrazoline conjugates was prepared and evaluated for their anti-breast cancer potential against estrogen responsive, i.e. MCF-7 (ER+), and triple-negative, i.e. MDA-MB-231 (ER-), cell lines. The structure-activity-relationship (SAR) was deduced based on the influence of linker length, substituents on the phenyl ring and the generated functionalities, on anti-proliferative activities. Docking simulations further delineate the type of interactions of the designed molecules with the selected targets. This report discloses the scope of triazole tethered naphthalimide-chalcone/pyrazoline conjugates as anti breast cancer agents.