Advances and future perspectives in epithelial drug delivery

Yousuf Mohammed; Amy Holmes; Philip Chi Lip Kwok; Tushar Kumeria; Sarika Namjoshi; Mohammad Imran; Lana Matteucci; Masood Ali; Waiting Tai; Heather A E Benson; Michael S Roberts

doi:10.1016/j.addr.2022.114293

Advances and future perspectives in epithelial drug delivery

Adv Drug Deliv Rev. 2022 Jul:186:114293. doi: 10.1016/j.addr.2022.114293. Epub 2022 Apr 26.

Authors

Affiliations

¹ Therapeutics Research Group, The University of Queensland Diamantina Institute, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia. Electronic address: y.mohammed@uq.edu.au.
² UniSA Clinical and Health Sciences, University of South Australia, Basil Hetzel Institute for Translational Health Research, Adelaide, South Australia, Australia.
³ Advanced Drug Delivery Group, Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2006, Australia.
⁴ School of Materials Science and Engineering, The University of New South Wales, Sydney, NSW 2052, Australia; Australian Centre for Nanomedicine, The University of New South Wales, Sydney NSW 2052, Australia.
⁵ Therapeutics Research Group, The University of Queensland Diamantina Institute, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.
⁶ Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.
⁷ UniSA Clinical and Health Sciences, University of South Australia, Basil Hetzel Institute for Translational Health Research, Adelaide, South Australia, Australia; Curtin Medical School, Curtin University, Perth, WA 6845, Australia.
⁸ Therapeutics Research Group, The University of Queensland Diamantina Institute, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia; UniSA Clinical and Health Sciences, University of South Australia, Basil Hetzel Institute for Translational Health Research, Adelaide, South Australia, Australia. Electronic address: m.roberts@uq.edu.au.

PMID: 35483435
DOI: 10.1016/j.addr.2022.114293

Abstract

Epithelial surfaces protect exposed tissues in the body against intrusion of foreign materials, including xenobiotics, pollen and microbiota. The relative permeability of the various epithelia reflects their extent of exposure to the external environment and is in the ranking: intestinal≈ nasal ≥ bronchial ≥ tracheal > vaginal ≥ rectal > blood-perilymph barrier (otic), corneal > buccal > skin. Each epithelium also varies in their morphology, biochemistry, physiology, immunology and external fluid in line with their function. Each epithelium is also used as drug delivery sites to treat local conditions and, in some cases, for systemic delivery. The associated delivery systems have had to evolve to enable the delivery of larger drugs and biologicals, such as peptides, proteins, antibodies and biologicals and now include a range of physical, chemical, electrical, light, sound and other enhancement technologies. In addition, the quality-by-design approach to product regulation and the growth of generic products have also fostered advancement in epithelial drug delivery systems.

Keywords: Biology and physiology of the Barriers; Epithelial barrier; Mucosal barrier; Ophthalmic drug delivery; Oral delivery; Otic drug delivery; Pulmonary and nasal delivery; Rectal drug delivery; Topical and transdermal d; Vaginal epithelial drug delivery.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Drug Delivery Systems*
Female
Humans
Permeability
Pharmaceutical Preparations / metabolism
Skin* / metabolism

Substances

Pharmaceutical Preparations