Can the SARS-CoV-2 Omicron Variant Confer Natural Immunity against COVID-19?

Molecules. 2022 Mar 29;27(7):2221. doi: 10.3390/molecules27072221.

Abstract

The coronavirus disease 2019 (COVID-19) pandemic is still ongoing, with no signs of abatement in sight. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of this pandemic and has claimed over 5 million lives, is still mutating, resulting in numerous variants. One of the newest variants is Omicron, which shows an increase in its transmissibility, but also reportedly reduces hospitalization rates and shows milder symptoms, such as in those who have been vaccinated. As a result, many believe that Omicron provides a natural vaccination, which is the first step toward ending the COVID-19 pandemic. Based on published research and scientific evidence, we review and discuss how the end of this pandemic is predicted to occur as a result of Omicron variants being surpassed in the community. In light of the findings of our research, we believe that it is most likely true that the Omicron variant is a natural way of vaccinating the masses and slowing the spread of this deadly pandemic. While the mutation that causes the Omicron variant is encouraging, subsequent mutations do not guarantee that the disease it causes will be less severe. As the virus continues to evolve, humans must constantly adapt by increasing their immunity through vaccination.

Keywords: COVID-19; Omicron; SARS-CoV-2; hybrid immunity; natural immunity.

Publication types

  • Review

MeSH terms

  • COVID-19* / epidemiology
  • Humans
  • Immunity, Innate
  • Pandemics
  • SARS-CoV-2 / genetics

Supplementary concepts

  • SARS-CoV-2 variants