Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19

Linzy Houchen-Wolloff; Krisnah Poinasamy; Kate Holmes; Maryrose Tarpey; Claire Hastie; Kelly Raihani; Natalie Rogers; Nikki Smith; Dawn Adams; Paul Burgess; Jean Clark; Clare Cranage; Mahadev Desai; Nicola Geary; Rhyan Gill; Jitendra Mangwani; Lily Staunton; Colin Berry; Charlotte E Bolton; Trudie Chalder; James Chalmers; Anthony De Soyza; Omer Elneima; John Geddes; Simon Heller; Ling-Pei Ho; Joseph Jacob; Hamish McAuley; Aarti Parmar; Jennifer K Quint; Betty Raman; Matthew Rowland; Amisha Singapuri; Sally J Singh; David Thomas; Mark R Toshner; Louise V Wain; Alex Robert Horsley; Michael Marks; Christopher E Brightling; Rachael A Evans

doi:10.1136/thoraxjnl-2021-218582

Joint patient and clinician priority setting to identify 10 key research questions regarding the long-term sequelae of COVID-19

Thorax. 2022 Jul;77(7):717-720. doi: 10.1136/thoraxjnl-2021-218582. Epub 2022 Mar 30.

Authors

Linzy Houchen-Wolloff^{1

2}, Krisnah Poinasamy³, Kate Holmes⁴, Maryrose Tarpey⁵, Claire Hastie⁶, Kelly Raihani⁶, Natalie Rogers⁶, Nikki Smith⁶, Dawn Adams⁷, Paul Burgess⁷, Jean Clark⁷, Clare Cranage⁷, Mahadev Desai⁷, Nicola Geary⁷, Rhyan Gill⁷, Jitendra Mangwani⁸, Lily Staunton⁷, Colin Berry⁹, Charlotte E Bolton¹⁰, Trudie Chalder¹¹, James Chalmers¹², Anthony De Soyza¹³, Omer Elneima^{1

2}, John Geddes¹⁴, Simon Heller¹⁵, Ling-Pei Ho^{16

17}, Joseph Jacob^{18

19}, Hamish McAuley^{1

2}, Aarti Parmar^{1

2}, Jennifer K Quint²⁰, Betty Raman²¹, Matthew Rowland²², Amisha Singapuri², Sally J Singh^{1

2}, David Thomas²³, Mark R Toshner^{24

25}, Louise V Wain^{2

26}, Alex Robert Horsley²⁷, Michael Marks²⁸, Christopher E Brightling^{1

2}, Rachael A Evans^{29

2}

Affiliations

¹ Respiratory Sciences, University of Leicester, Leicester, UK.
² NIHR Leicester Biomedical Research Centre - Respiratory, University of Leicester, Leicester, UK.
³ Research and Innovation Advocacy, Asthma & Lung UK, London, UK.
⁴ Office for Clinical Research Infrastructure (NOCRI), National Institute for Health Research, London, UK.
⁵ James Lind Alliance, University of Southampton, Southampton, UK.
⁶ Long Covid Support, NIHR Leicester Biomedical Research Centre - Respiratory, Leicester, UK.
⁷ Patient and Public Involvement Group, NIHR Leicester Biomedical Research Centre - Respiratory, Leicester, UK.
⁸ Leicester Orthopaedic Research Network, University Hospitals of Leicester NHS Trust, Leicester, UK.
⁹ British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
¹⁰ Respiratory Medicine, NIHR Nottingham Biomedical Research Centre Respiratory Theme, University of Nottingham, Nottingham, UK.
¹¹ Pyschological Medicine, King's College London, London, UK.
¹² Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.
¹³ Lung Biology and Transplantation Group, Newcastle University, Newcastle upon Tyne, UK.
¹⁴ Department of Psychiatry, University of Oxford, Oxford, UK.
¹⁵ Department of Oncology and Metabolism, The University of Sheffield, Sheffield, UK.
¹⁶ Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford, UK.
¹⁷ Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford, UK.
¹⁸ Centre for Medical Imaging and Computing, University College London, London, UK.
¹⁹ Department of Respiratory Medicine, University College London, London, UK.
²⁰ Respiratory Epidemiology, Occupational Medicine and Public Health, Imperial College London, London, UK.
²¹ Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
²² Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
²³ Department of Immunology and Inflammation, Imperial College London, London, UK.
²⁴ Pulmonary Vascular Disease Unit, Papworth Hospital NHS Foundation Trust, Cambridge, UK.
²⁵ School of Clinical Medicine, University of Cambridge, Cambridge, UK.
²⁶ Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, UK.
²⁷ Respiratory Medicine, Manchester University NHS Foundation Trust, Manchester, UK.
²⁸ Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.
²⁹ Respiratory Sciences, University of Leicester, Leicester, UK re66@leicester.ac.uk.

Abstract

Given the large numbers of people infected and high rates of ongoing morbidity, research is clearly required to address the needs of adult survivors of COVID-19 living with ongoing symptoms (long COVID). To help direct resource and research efforts, we completed a research prioritisation process incorporating views from adults with ongoing symptoms of COVID-19, carers, clinicians and clinical researchers. The final top 10 research questions were agreed at an independently mediated workshop and included: identifying underlying mechanisms of long COVID, establishing diagnostic tools, understanding trajectory of recovery and evaluating the role of interventions both during the acute and persistent phases of the illness.

Keywords: COVID-19.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
COVID-19* / complications
Caregivers
Disease Progression
Health Priorities
Humans
Post-Acute COVID-19 Syndrome
Research Personnel

Abstract

Publication types

MeSH terms

Grants and funding