A Case Report of Post-Radiotherapy c-MYC-Positive Angiosarcoma of the Breast

Edna Retter; Carol-Ann Benn; Christopher Maske; Bernardo Leon Rapoport

doi:10.1159/000521069

A Case Report of Post-Radiotherapy c-MYC-Positive Angiosarcoma of the Breast

Case Rep Oncol. 2022 Feb 7;15(1):62-70. doi: 10.1159/000521069. eCollection 2022 Jan-Apr.

Authors

Edna Retter^{1

2}, Carol-Ann Benn^{2

3}, Christopher Maske^{2

4}, Bernardo Leon Rapoport^{2

5

6}

Affiliations

¹ Oncocare, Johannesburg, South Africa.
² Netcare Breast Care Centre of Excellence, Milpark Hospital, Johannesburg, South Africa.
³ Helen Joseph Hospital Breast Care Clinic, Department of Surgery, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
⁴ QLAB Laboratory, Johannesburg, South Africa.
⁵ The Medical Oncology Centre of Rosebank, Johannesburg, South Africa.
⁶ Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Abstract

Angiosarcoma of the breast is an unusual malignancy and carries a poor prognosis, with a 5-year overall survival rate ranging from 27 to 48%. Radiotherapy-induced angiosarcoma (RIAS) of the breast is very uncommon, with an estimated incidence of 1 in 1,000 cases of breasts treated with radiotherapy for breast cancer. The increase in radiotherapy usage may lead to an increased incidence of RIAS. A case presentation of a 67-year-old patient with tubular adenocarcinoma of the left breast who developed c-MYC-positive RIAS of the breast is presented. The patient was successfully treated with surgery. We presented a classic case of c-MYC RIAS. c-MYC was reported to be positive in RIAS and other types of angiosarcomas. Clinical examination and early detection of RIAS breast angiosarcoma is vital to improving outcomes in these patients.

Keywords: Breast angiosarcoma; MYC positive; Post-radiotherapy.

Publication types

Case Reports