Noncoding RNAs in age-related cardiovascular diseases

Amela Jusic; Pınar Buket Thomas; Stephanie Bezzina Wettinger; Soner Dogan; Rosienne Farrugia; Carlo Gaetano; Bilge Güvenç Tuna; Florence Pinet; Emma L Robinson; Simon Tual-Chalot; Konstantinos Stellos; Yvan Devaux; EU-CardioRNA COST Action CA17129

doi:10.1016/j.arr.2022.101610

Noncoding RNAs in age-related cardiovascular diseases

Ageing Res Rev. 2022 May:77:101610. doi: 10.1016/j.arr.2022.101610. Epub 2022 Mar 23.

Affiliations

¹ Cardiovascular Research Unit, Luxembourg Institute of Health, Strassen, Luxembourg.
² Department of Medical Biology and Genetics, Maltepe University Faculty of Medicine, Istanbul, Turkey.
³ Department of Applied Biomedical Science, Faculty of Health Sciences, University of Malta, Msida, Malta.
⁴ Department of Medical Biology, School of Medicine, Yeditepe University, Istanbul, Turkey.
⁵ Laboratory of Epigenetics, Istituti Clinici Scientifici Maugeri IRCCS, Via Maugeri 10, 27100 Pavia, Italy.
⁶ Department of Biophysics, School of Medicine, Yeditepe University, Istanbul, Turkey.
⁷ INSERM, University of Lille, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000 Lille, France.
⁸ Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
⁹ Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK.
¹⁰ Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK; Department of Cardiology, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.
¹¹ Cardiovascular Research Unit, Luxembourg Institute of Health, Strassen, Luxembourg. Electronic address: yvan.devaux@lih.lu.

PMID: 35338919
DOI: 10.1016/j.arr.2022.101610

Abstract

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality in the adult population worldwide and represent a severe economic burden and public health concern. The majority of human genes do not code for proteins. However, noncoding transcripts play important roles in ageing that significantly increases the risk for CVDs. Noncoding RNAs (ncRNAs) are critical regulators of multiple biological processes related to ageing such as oxidative stress, mitochondrial dysfunction and chronic inflammation. NcRNAs are also involved in pathophysiological developments within the cardiovascular system including arrhythmias, cardiac hypertrophy, fibrosis, myocardial infarction and heart failure. In this review article, we cover the roles of ncRNAs in cardiovascular ageing and disease as well as their potential therapeutic applications in CVDs.

Keywords: Ageing; Cardiovascular disease; Inflammageing; Noncoding RNAs.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Aging / genetics
Cardiovascular Diseases* / genetics
Cardiovascular System* / metabolism
Heart
Humans
MicroRNAs* / genetics
RNA, Long Noncoding* / genetics
RNA, Untranslated / genetics

Substances

MicroRNAs
RNA, Long Noncoding
RNA, Untranslated