CD4+ chimeric antigen receptor T cells in for the long journey

Amanda Xy Chen; Emily B Derrick; Paul A Beavis; Imran G House

doi:10.1111/imcb.12545

CD4⁺ chimeric antigen receptor T cells in for the long journey

Immunol Cell Biol. 2022 May;100(5):304-307. doi: 10.1111/imcb.12545. Epub 2022 Apr 16.

Authors

Amanda Xy Chen^{1

2}, Emily B Derrick^{1

2}, Paul A Beavis^{1

2}, Imran G House^{1

2}

Affiliations

¹ Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
² Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia.

PMID: 35307873
DOI: 10.1111/imcb.12545

Abstract

In a recently published article, Melenhorst et al. performed a longitudinal analysis on chimeric antigen receptor (CAR) T cells isolated from patients over 10 years after therapy, revealing expansion of a long-lived CD4⁺ CAR T-cell population with a cytotoxic phenotype.

Keywords: chimeric antigen receptor T cells; cytotolytic CD4+ T cells; persistence.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

CD4-Positive T-Lymphocytes
Humans
Immunotherapy, Adoptive
Receptors, Antigen, T-Cell
Receptors, Chimeric Antigen* / genetics
T-Lymphocytes

Substances

Receptors, Antigen, T-Cell
Receptors, Chimeric Antigen