Wound-related complications in the surgical treatment of vertebral metastatic disease - A case series analysis

N Molho; M Pereira-Duarte; M Estefan; J Perez-Abdala; G Kido; M Petracchi; M Gruenberg; C Sola; J P Cabrera; G Camino-Willhuber

doi:10.1016/j.recot.2021.10.003

Wound-related complications in the surgical treatment of vertebral metastatic disease - A case series analysis

Rev Esp Cir Ortop Traumatol. 2022 Nov-Dec;66(6):438-444. doi: 10.1016/j.recot.2021.10.003. Epub 2022 Mar 8.

[Article in English, Spanish]

Authors

Affiliations

¹ Orthopaedic and Traumatology Department, Institute of Orthopedics "Carlos E. Ottolenghi," Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
² The Centre for Spinal Studies and Surgery (CSSS), Queen's Medical Centre, Nottingham University Hospitals NHS, UK.
³ Department of Neurosurgery, Hospital Clínico Regional de Concepción, Concepción, Chile.
⁴ Orthopaedic and Traumatology Department, Institute of Orthopedics "Carlos E. Ottolenghi," Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. Electronic address: gaston.camino@hospitalitaliano.org.ar.

PMID: 35277370
DOI: 10.1016/j.recot.2021.10.003

Abstract

Introduction and objectives: Spinal metastases (SM) account for 5-30% of patients with cancer, causing pain, deformity and/or neurological deficit. Postoperative complications are a concerning subject and wound-related complications (WRC) may delay adjuvant treatment. The objective of this study was to analyze the incidence of WRC in patients with SM that underwent surgical treatment as well as possible risk factors related to the occurrence of complications.

Materials and methods: Patients with SM operated between 2011 and 2021 were analyzed. Demographics characteristics, primary tumor, general and neurological status, Tokuhashi score, type of surgical treatment, surgical length, preoperative serum albumin and hemoglobin, pre and postoperative adjuvant treatment were analyzed. The incidence and risk factors of WRC - surgical site infection, hematoma, and/or dehiscence - at 90 days was evaluated. Patients were classified in two groups according to the absence/presence of WRC.

Results: 198 patients (121 males and 77 females) with an average age of 65 years (range 54-73 years) were analyzed. WRC were observed in 44 patients (22%). On multivariable analysis, significant predictors for developing WRC were low Tokuhashi score (OR=7.89, 95% CI=1.37-45.35, p=0.021), prostate cancer as primary tumor (6.73, 1.14-39.65, p=0.035), and preoperative serum albumin level ≤3.5g/dL (2.31, 1.02-5.22, p=0.044). There was no difference between groups on 90 days survival rate (p=0.714).

Conclusions: In our series, the incidence of WRC was 22%, main risk factors for complications were low Tokuhashi score, lower preoperative serum albumin, and prostate cancer. Finally, short-term survival rate was not affected by the occurrence of WRC.

Keywords: Complicación de la herida; Enfermedad metastásica vertebral; Infección del sitio quirúrgico; Surgical site infection; Vertebral metastatic disease; Wound complication.