The Diagnostic Performance of Maximum Uptake Value and Apparent Diffusion Coefficient in Differentiating Benign and Malignant Ovarian or Adnexal Masses: A Meta-Analysis

Xianwen Hu; Zhigang Liang; Chuanqin Zhang; Guanlian Wang; Jiong Cai; Pan Wang

doi:10.3389/fonc.2022.840433

The Diagnostic Performance of Maximum Uptake Value and Apparent Diffusion Coefficient in Differentiating Benign and Malignant Ovarian or Adnexal Masses: A Meta-Analysis

Front Oncol. 2022 Feb 9:12:840433. doi: 10.3389/fonc.2022.840433. eCollection 2022.

Authors

Xianwen Hu¹, Zhigang Liang¹, Chuanqin Zhang¹, Guanlian Wang², Jiong Cai¹, Pan Wang¹

Affiliations

¹ Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
² Research and Development Department, Jiangsu Yuanben Biotechnology Co., Ltd., Zunyi, China.

Abstract

Objective: The purpose of this meta-analysis was to provide evidence for using maximum uptake value (SUVmax) and apparent diffusion coefficient (ADC) to quantitatively differentiate benign and malignant ovarian or adnexal masses, and to indirectly compare their diagnostic performance.

Material and methods: The association between SUVmax, ADC and ovarian or adnexal benign and malignant masses was searched in PubMed, Cochrane Library, and Embase databases until October 1, 2021. Two authors independently extracted the data. Studies included in the analysis were required to provide data for the construction of a 2 × 2 contingency table to evaluate the diagnostic performance of SUVmax or ADC in differentiating benign and malignant ovarian or adnexal masses. The quality of the enrolled studies was evaluated by Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) instrument, and the meta-analysis was conducted using Stata software version 14.0. Forest plots were generated according to the sensitivity and specificity of SUVmax and ADC, and meta-regression analysis was further used to assess heterogeneity between studies.

Results: A total of 14 studies were finally included in this meta-analysis by gradually excluding duplicate literatures, conference abstracts, guidelines, reviews, case reports, animal studies and so on. The pooled sensitivity and specificity of SUVmax for quantitative differentiation of benign and malignant ovarian or adnexal masses were 0.88 and 0.89, respectively, and the pooled sensitivity and specificity for ADC were 0.87 and 0.80, respectively.

Conclusion: Quantitative SUVmax and ADC values have good diagnostic performance in differentiating benign and malignant ovarian or adnexal masses, and SUVmax has higher accuracy than ADC. Future prospective studies with large sample sizes are needed for the analysis of the role of SUVmax and ADC in the differentiation of benign and malignant ovarian or adnexal masses.

Keywords: PET/CT; apparent diffusion coefficient; diffusion weighted imaging; maximum uptake value; ovarian cancer.

Publication types

Systematic Review