Treatment of primary hyperparathyroidism in a Miniature Horse using chemical ablation of abnormal parathyroid tissue localized by 3-phase computed tomography

J Vet Intern Med. 2022 Mar;36(2):798-804. doi: 10.1111/jvim.16390. Epub 2022 Feb 12.

Abstract

A 15-year-old Miniature Horse mare with persistently increased plasma calcium (total and ionized) and serum parathyroid hormone concentrations was presented for suspected primary hyperparathyroidism. Ultrasonography of the thyroid region identified an enlarged heterogeneous mass axial to the right thyroid lobe suggestive of an enlarged parathyroid gland, which was further confirmed using sestamibi nuclear scintigraphy and 3-phase computed tomography. Percutaneous ultrasound-guided ethanol ablation of the mass, a method not previously described in the horse, was performed under general anesthesia resulting in rapid normalization of plasma ionized calcium and serum parathyroid hormone concentrations. Ablation of abnormal parathyroid gland tissue may be a suitable alternative to surgical resection in certain cases of primary hyperparathyroidism in the horse.

Keywords: adenoma; equine; ethanol; hypercalcemia; parathyroid hormone.

Publication types

  • Case Reports

MeSH terms

  • Adenoma* / veterinary
  • Animals
  • Female
  • Horse Diseases* / diagnostic imaging
  • Horse Diseases* / surgery
  • Horses
  • Hyperparathyroidism, Primary* / veterinary
  • Parathyroid Glands / diagnostic imaging
  • Parathyroid Glands / surgery
  • Parathyroid Hormone
  • Parathyroid Neoplasms* / diagnostic imaging
  • Parathyroid Neoplasms* / surgery
  • Parathyroid Neoplasms* / veterinary
  • Technetium Tc 99m Sestamibi
  • Tomography, X-Ray Computed / veterinary
  • Ultrasonography

Substances

  • Parathyroid Hormone
  • Technetium Tc 99m Sestamibi