Clinical evaluation of autonomous, unsupervised planning integrated in MR-guided radiotherapy for prostate cancer

Luise A Künzel; Marcel Nachbar; Markus Hagmüller; Cihan Gani; Simon Boeke; Daniel Wegener; Frank Paulsen; Daniel Zips; Daniela Thorwarth

doi:10.1016/j.radonc.2022.01.036

Clinical evaluation of autonomous, unsupervised planning integrated in MR-guided radiotherapy for prostate cancer

Radiother Oncol. 2022 Mar:168:229-233. doi: 10.1016/j.radonc.2022.01.036. Epub 2022 Feb 5.

Authors

Luise A Künzel¹, Marcel Nachbar¹, Markus Hagmüller¹, Cihan Gani², Simon Boeke², Daniel Wegener², Frank Paulsen², Daniel Zips³, Daniela Thorwarth⁴

Affiliations

¹ Section for Biomedical Physic, Department of Radiation Oncology, University Hospital Tübingen, Germany.
² Department of Radiation Oncology, University Hospital Tübingen, Germany.
³ Department of Radiation Oncology, University Hospital Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tübingen, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁴ Section for Biomedical Physic, Department of Radiation Oncology, University Hospital Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tübingen, and German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: Daniela.thorwarth@med.uni-tuebingen.de.

PMID: 35134447
DOI: 10.1016/j.radonc.2022.01.036

Abstract

This retrospective study aimed at clinical evaluation of autonomous radiotherapy planning for ten prostate cancer cases, including organ-at-risk/target contouring and treatment planning. Five experts scored the clinical acceptability of each step using a 4-level Likert-scale resulting in 78%, 66% and 90% acceptance. For 6/10 patients the entire workflow was considered acceptable.

Keywords: Automatic segmentation; Autonomous radiotherapy planning; MR-Linac; MR-guided-RT; Particle swarm optimization.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Magnetic Resonance Imaging / methods
Male
Prostatic Neoplasms* / radiotherapy
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted / methods
Radiotherapy, Image-Guided* / methods
Retrospective Studies