New Insights into LINC00346 and its Role in Disease

Juan Lu; Zhaoying Xiao; Mengqiu Xu; Lanjuan Li

doi:10.3389/fcell.2021.819785

New Insights into LINC00346 and its Role in Disease

Front Cell Dev Biol. 2022 Jan 13:9:819785. doi: 10.3389/fcell.2021.819785. eCollection 2021.

Authors

Juan Lu¹, Zhaoying Xiao², Mengqiu Xu², Lanjuan Li¹

Affiliations

¹ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
² Department of Infectious Diseases Shengzhou People' Hospital, Shengzhou Branch, The Fisrt Affiliated Hospital of Zhejiang University, Shengzhou, China.

Abstract

Accumulating evidence has shown that long intergenic non-protein-coding RNA 346 (LINC00346) functions as an oncogene in the tumorigenesis of several cancers. The expression level of LINC00346 has been shown to be obviously correlated with prognosis, lymphoma metastasis, histological grade, TNM stage, tumor size and pathologic stage. LINC00346 has been found to regulate specific cellular functions by interacting with several molecules and signaling pathways. In this review, we summarize recent evidence concerning the role of LINC00346 in the occurrence and development of diseases. We also discuss the potential clinical utility of LINC00346, thereby providing new insight into the diagnosis and treatment of diseases. In addition, we further discuss the potential clinical utility of LINC00346 in the diagnosis, prognostication, and treatment of diseases.

Keywords: LINC00346; biological function; clinical utility; lncRNA; mechanism.

Publication types

Review