Aberrant Expression of miR-1301 in Human Cancer

Chenming Zhong; Yiyao Dong; Qiudan Zhang; Chunhui Yuan; Shiwei Duan

doi:10.3389/fonc.2021.789626

Aberrant Expression of miR-1301 in Human Cancer

Front Oncol. 2022 Jan 5:11:789626. doi: 10.3389/fonc.2021.789626. eCollection 2021.

Authors

Chenming Zhong^{1

2}, Yiyao Dong², Qiudan Zhang², Chunhui Yuan¹, Shiwei Duan^{1

2

3}

Affiliations

¹ Department of Clinical Medicine, Zhejiang University City College School of Medicine, Hangzhou, China.
² Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, China.
³ Institute of Translational Medicine, Zhejiang University City College, Hangzhou, China.

Abstract

miR-1301 is a newly discovered miRNA, which is abnormally expressed in 14 types of tumors. miR-1301 inhibits 23 target genes, forms a ceRNA network with 2 circRNAs and 8 lncRNAs, and participates in 6 signaling pathways, thereby affecting tumor cell proliferation, invasion, metastasis, apoptosis, angiogenesis, etc. Abnormal expression of miR-1301 is often associated with poor prognosis of cancer patients. In addition, miR-1301 is related to the anti-tumor effect of epirubicin on osteosarcoma and imatinib on chronic myeloid leukemia(CML) and can enhance the cisplatin sensitivity of ovarian cancer. This work systematically summarizes the abnormal expression and prognostic value of miR-1301 in a variety of cancers, depicts the miR-1301-related signaling pathways and ceRNA network, and provides potential clues for future miR-1301 research.

Keywords: cancer; ceRNA; miR-1301; prognosis; signaling pathway.

Publication types

Review