Macro-B12 masking B12 deficiency

Abstract

In clinical practice, the finding of an elevated serum B₁₂ concentration is often the consequence of supplementation with B₁₂ in either oral form or injections. Also, elevated serum B₁₂ may be associated with underlying disorders, like liver diseases or a (haematologic) malignancy. Only a few studies have shown that it may also be the consequence of complex formation of B₁₂-vitamin binding proteins with immunoglobulins, the so-called macro-B₁₂ We describe a young woman who previously was diagnosed with B₁₂ deficiency, and in whom, after cessation of B₁₂ injection treatment, neurologic symptoms re-appeared, and despite this, repeatedly elevated serum B₁₂ concentrations above the upper limit of the assay were found. We demonstrated that this was caused by the presence of macro-B₁₂, which not only resulted in erroneous and longstanding elevated serum B₁₂, but also masked her underlying B₁₂ deficiency.

Keywords: metabolic disorders; vitamins and supplements.