To date, the common etiological factor of periodontal disease is periodontopathogenic microflora. In the case of favorable circumstances (the presence of systemic diseases, reduced general or local resistance), it multiplies rapidly and causes periodontal disease: gingivitis or periodontitis. Among these systemic lesions, psychological stress occupies a significant place. This should be taken into account in the complex treatment of patients with generalized periodontitis. In view of this, a drug regimen for the preparation of patients with generalized periodontitis of exacerbative course with the presence of psychoemotional stress with the use of a modified complex of adrenoblockers.Aim of the study: to determine the nearest results of clinical efficacy of the modified proposed complex of adrenoblockers in the complex treatment of patients with generalized periodontitis of exacerbative course in the presence of psychoemotional stress.This clinical study was conducted in a groupof 70 patients with generalized periodontitis of I-II stage, exacerbative course and manifestations of psychological stress. Drug treatment was performed using a modified proposed premedication complex adrenoblockers. A comprehensive examination of the periodontal tissues of patients before and after treatment was performed. To assess the clinical effectiveness of treatment used Schiller-Pisarev test, PMA index by C. Parma (1961), hygienic index OHI-S (J.C. Green, J.R. Vermillion, 1964), PBI index (H.R. Mühlemann, S.Son, 1971), periodontal index PI (A.L. Russel, 1956). The level of psychological stress was assessed using questionnaires DASS-21 and Spielberger-Khanin.It was found that the inclusion of the proposed modified premedication complex adrenoblockers in the complex therapy of patients with generalized periodontitis of exacerbative course with manifestations of psychoemotional stress can effectively suppress the dystrophic-inflammatory process in periodontal tissues. This confirms the decrease in the indices of PMA, OHI-S, PBI, PI in the near future.The use of the proposed modified premedication with a complex of adrenoblockers can increase the effectiveness of treatment of patients with generalized periodontitis of exacerbative course with manifestations of psychoemotional stress.