Purpose: Willingness-to-pay (WTP) analyses can support allocation processes considering the patients preferences in personalized medicine. However, genetic testing especially might imply ethical concerns that have to be considered. Methods: A WTP questionnaire was designed to compare preferences for imaging and genetic testing in cancer patients and to evaluate potential ethical concerns. Results: Comparing the options of imaging and genetics showed comparable WTP values. Ethical concerns about genetic testing seemed to be minor. Treatment success was the top priority irrespective of the diagnostic modality. In general, the majority of patients considered personalized medicine to be beneficial. Conclusion: Most patients valued personalized approaches and rated the benefits of precision medicine of overriding importance irrespective of modality or ethical concerns.
Keywords: PET/CT; PET/MRI; ethical concerns; genetic testing; genomics; imaging; next-generation sequencing; personalized medicine; radiation oncology; resource allocation.
A study of the patients preferences in diagnostic approaches where patients were asked if they would hypothetically pay out-of-pocket money for particular procedures. However, in regard to personalized medicine (specifically selected for a single person) genetic testing especially might imply ethical concerns. A questionnaire was designed to compare preferences for imaging and genetic testing in cancer patients and to evaluate potential ethical concerns. Comparing the options of imaging and genetics showed comparable values of out-of-pocket money the patients were willing to pay. Ethical concerns about genetic testing were minor. Treatment success was the top priority irrespective of the diagnostic modality. Most patients valued personalized approaches and rated the benefits of overriding importance irrespective of modality or ethical concerns.