Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

Nature. 1987;328(6129):395-9. doi: 10.1038/328395a0.

Abstract

A detailed analysis of the residues within an immunogenic peptide that endow it with the capacity to interact with Ia and to be recognized by T cells is presented. Ia interacts with only a few of the peptide residues and overall exhibits a very broad specificity. Some residues appear to interact both with Ia and with T cells, leading to a model in which a peptide antigen is 'sandwiched' between Ia and the T-cell receptor.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens / immunology*
  • Binding, Competitive
  • Histocompatibility Antigens Class II / immunology*
  • Hybridomas / immunology
  • Ovalbumin / immunology*
  • Peptide Fragments / immunology
  • Peptides / immunology*
  • Structure-Activity Relationship
  • T-Lymphocytes / immunology*

Substances

  • Antigens
  • Histocompatibility Antigens Class II
  • Peptide Fragments
  • Peptides
  • Ovalbumin