Abstract
Mupirocin induced expression of genes encoding efflux pumps NorA and MepA as well as a yellow fluorescent protein (YFP) fluorescence reporter of NorA. Mupirocin exposure also produced reduced susceptibility to pump substrates ciprofloxacin and chlorhexidine, a change that was dependent on intact norA and mepA, respectively.
Keywords:
MepA; NorA; Staphylococcus aureus; chlorhexidine; ciprofloxacin; mupirocin.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Chlorhexidine / pharmacology
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Ciprofloxacin* / metabolism
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Ciprofloxacin* / pharmacology
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Microbial Sensitivity Tests
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Multidrug Resistance-Associated Proteins / genetics
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Mupirocin / pharmacology
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Staphylococcus aureus* / genetics
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Staphylococcus aureus* / metabolism
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Multidrug Resistance-Associated Proteins
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Ciprofloxacin
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Mupirocin
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Chlorhexidine