Current HLA Investigations on SARS-CoV-2 and Perspectives

Venceslas Douillard; Erick C Castelli; Steven J Mack; Jill A Hollenbach; Pierre-Antoine Gourraud; Nicolas Vince; Sophie Limou; Covid-19|HLA & Immunogenetics Consortium and the SNP-HLA Reference Consortium

doi:10.3389/fgene.2021.774922

Current HLA Investigations on SARS-CoV-2 and Perspectives

Front Genet. 2021 Nov 29:12:774922. doi: 10.3389/fgene.2021.774922. eCollection 2021.

Authors

Venceslas Douillard¹, Erick C Castelli², Steven J Mack³, Jill A Hollenbach⁴, Pierre-Antoine Gourraud¹, Nicolas Vince¹, Sophie Limou^{1

5}; Covid-19|HLA & Immunogenetics Consortium and the SNP-HLA Reference Consortium

Affiliations

¹ Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, Nantes, France.
² Unesp - Universidade Estadual Paulista, Botucatu-SP, Brazil.
³ Division of Allergy, Immunology and Bone Marrow Transplantation, Department of Pediatrics, School of Medicine, University of California, San Francisco, CA, United States.
⁴ Department of Neurology, University of California, San Francisco and Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, United States.
⁵ Ecole Centrale de Nantes, Department of Computer Sciences and Mathematics in Biology, Nantes, France.

Abstract

The rapid, global spread of the SARS-CoV-2 virus during the current pandemic has triggered numerous efforts in clinical and research settings to better understand the host genetics' interactions and the severity of COVID-19. Due to the established major role played by MHC/HLA polymorphism in infectious disease course and susceptibility, immunologists and geneticists have teamed up to investigate its contribution to the SARS-CoV-2 infection and COVID-19 progression. A major goal of the Covid-19|HLA & Immunogenetics Consortium is to support and unify these efforts. Here, we present a review of HLA immunogenomics studies in the SARS-CoV-2 pandemic and reflect on the role of various HLA data, their limitation and future perspectives.

Keywords: COVID-19; HLA; MHC; SARS- CoV-2; association analysis; immunogenetics.

Publication types

Review

Abstract

Publication types

Grants and funding