The Rise of Factor X Level in Blood Plasma of Patients at Severe Burn Injuries

Abstract

This work is dedicated to the detection of imbalance between the pro- and anticoagulant branches of hemostasis at severe burn injuries by evaluating the content or activity of individual clotting factors. To select the targets for accurate diagnostics we measured the concentrations of soluble fibrin monomeric complexes and fibrinogen, levels of total prothrombin, factor X, protein C, and antithrombin III, and recorded the time of clotting in activated partial thromboplastin time and prothrombin time (PT) tests. Factor X level was increased in 26% of patients on the 1st day after the burn and it rose further in 62% patients on the 14th day of recovery. Increasing factor X level is assumed to be a risk factor of thrombotic complications. We propose to use it as a marker of predisposition to thrombosis at severe burn injury.